Clark’s Botanicals

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DNA-42 Clinicalift Serum™DNA-42 Clinicalift Serum™DNA-42 Clinicalift Serum™DNA-42 Clinicalift Serum™DNA-42 Clinicalift Serum™DNA-42 Clinicalift Serum™DNA-42 Clinicalift Serum™DNA-42 Clinicalift Serum™

DNA-42 Clinicalift Serum™

$150.00
★★★★★(6)
Harper’s BazaarBest New Serum 2026
AllureBest for Sensitive Skin 2026

or 4 interest-free payments of $37.50 with Afterpay

In 42 days, skin appears up to 8 years younger.

A serum powered by vegan dual PDRN regenerative science and plant-derived exosome delivery technology, engineered to visibly lift, redensify and restore skin by activating cellular renewal at its source.

Not slowing how skin ages. Visibly turning back how it looks.

42 days. Proven. Measured.

Why Clark's Botanicals+

60-DAY MONEY GUARANTEE

We understand that sometimes an item that was purchased is not right for you. You have 60 days to return it and receive a refund.

CLINICALLY PROVEN

Our products have been tested and proven to provide noticeable and satisfying results.

VEGAN AND NATURAL

We are dedicated to delivering the purest and most natural ingredients for your skincare needs.

Shipping and Returns+

SHIPPING AND HANDLING INFORMATION

United States

Rate name

Condition Transit time Price
Economy
5 to 8 business days

$5.00

United Kingdom

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Condition Price
International Shipping $100.00 and up

$25.00

International Shipping $0.00–$99.99

$35.00

Canada

Rate name

Condition Price
International Shipping $0.00–$99.99

$35.00

International Shipping $100.00–$199.99

$15.00

Rest of World

Rate name

Condition Price
International Shipping —

$35.00


Multiple addresses

At this time, we do not ship to more than one address per order.


Maximum Purchase

You may purchase up to five units of each item.


Sales Tax

We are required by law to apply sales tax to orders (including shipping & handling) for the following states: NJ, NY, PA, TX.

RETURNS

Full Returns within 30 days for Domestic Orders on ClarksBotanicals.com: We understand that skincare is a personal purchase. Sometimes an item that was purchased is not right for you. Please email cs@clarksbotanicals.com for a pre-paid shipping label for your return and we will issue a full refund to your original form of payment.

  • Your satisfaction is our top priority. In case you are not 100% satisfied with any of our products, you may return the product(s) that is/are more than half full for a full refund within 30 days after receiving your purchase.
  • We are so committed to your satisfaction that we will cover the cost of your return shipping – please contact cs@clarksbotanicals.com for a return shipping label
  • Refunds are processed to the card/method of payment that was used in the original order.
  • If the product is a gift, we can refund it via a gift card using the name of the purchaser or order number
  • Empty bottles/tubes of products cannot be accepted.
  • You may not receive a (full) refund in cases where the product has been used beyond what is deemed reasonable to trial the product. For example, a product that is empty or almost empty. This also applies to a product that has been damaged after you have received it.
  • Returns that exceed the 60 day guarantee period cannot be accepted.
  • We do not accept returns from orders placed via a reseller.
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76%repurchase rate
60-daymoney-back guarantee
Leaping Bunnycertified cruelty free

Available at Bluemercury · Credo · Saks Fifth Avenue · Goop

Pairs well with

Description+

Repair the Biology. Reverse the Damage. Reclaim Your Skin.

A physician-formulated regenerative serum that visibly lifts, densifies, and restores skin not by masking the signs of aging, but by activating the biological pathways responsible for structural renewal.

Long before "longevity skincare" became a trend, Clark's Botanicals was studying the cellular resilience mechanisms of the Amalfi Coast, one of the world's most biodiverse and protected coastal ecosystems, and translating them into measurable pathways for human skin. In this uniquely protected environment, botanicals and marine organisms thrive under constant environmental stress. DNA-42 captures the science behind that survival.

DNA-42 Clinicalift™ Serum is the first expression of Amalfi Born Biotechnology™, and the first topical serum to combine plant-derived exosome delivery technology with a Vegan PDRN regenerative complex. Together, they ensure that repair signals reach the dermal cells where visible renewal truly begins. Polydeoxyribonucleotide (PDRN) has long been studied in regenerative dermatology historically sourced from animal tissue.

DNA-42 advances this science entirely: our plant-derived Vegan PDRN complex, drawn from rice and barley, is clinically shown to outperform legacy animal-derived formulations in collagen synthesis, fibroblast vitality, and epidermal renewal. This is not an ethical compromise. It is a clinically superior evolution. The result is a serum that works with your skin's biology not against it. Skin appears smoother, clearer, and more luminous not because something has been erased, but because the skin's own structural vitality has been rebuilt.

Your skin's been keeping score. DNA-42 is here to settle it.

How to Use+

Apply 3-5 drops to cleansed face AM and/or PM. Press gently into skin using fingertips, working outward from the center of the face. Allow to absorb fully before layering moisturizer or SPF.

For optimal results, use consistently through a complete 42-day renewal cycle. Do not interrupt the cycle, visible structural change requires the full biological timeline.

Pro Tip: Unlike retinol or strong acid treatments, DNA-42 works with your skin's biology rather than against it. There is no downtime, no cycling, and no irritation phase. You can layer it with your existing routine from day one. Sensitive skin approved.

BENEFITS+

• Visibly lifts and firms contours across a complete 42-day renewal cycle
• Stimulates collagen synthesis and supports extracellular matrix reinforcement
• Reduces visible wrinkle depth and softens expression lines
• Increases dermal density and improves structural integrity from within
• Restores skin vitality: smoothness, clarity, tone, and luminosity
• Strengthens the skin's barrier integrity and epidermal resilience
• Activates cellular repair and improves intercellular communication
• No irritation. Safe for sensitive skin. Suitable for all skin types.

CLINICALS+

Clinically Measured. 42 Days. No Irritation.
Tested using advanced reconstructed human skin models designed to replicate human biological response. Compared to traditional animal-derived PDRN systems, the Vegan Dual PDRN Complex in DNA-42 demonstrates:

+266% Acceleration in visible cellular repair.
+200% Increase in collagen synthesis
+180% Acceleration in epidermal renewal
+115% Enhancement in fibroblast vitality
+111% Strengthening of visible skin resilience
+90% Improvement in intercellular communication
8.2 years Skin age reversal with Decrease in visible wrinkle depth vs. baseline (independent analysis, 42 days)

VISIBLE PROGRESSION+

Day 1: Deep hydration and immediately refined texture. Skin feels plumped and prepared.

Day 14: Improved elasticity and smoother surface appearance. Lines appear softened.

Day 42: Visibly lifted contours. Increased dermal density. Softened expression lines. Strengthened barrier integrity. Skin appears up to 8 years younger.

KEY INGREDIENTS+

Vegan PDRN Complex — Sodium DNA (Rice-Derived) + Hydrolyzed DNA (Barley-Derived): A plant-derived evolution of polydeoxyribonucleotide technology, clinically shown to outperform traditional animal-derived PDRN in fibroblast stimulation, collagen synthesis, and epidermal
renewal rate. This is not an ethical substitute for legacy technology. It is a clinically superior advancement of regenerative DNA science, delivering +200% increase in collagen synthesis and +266% acceleration in cellular repair vs. legacy formulations.

Plant Exosome Delivery Technology — Lycium Barbarum Callus Culture Extract (Phytocelltec™): Stem cell–derived phospholipid vesicle structures that enhance cellular communication and deepen the penetration of high molecular weight actives, including Vegan PDRN. The same delivery mechanism at the forefront of aesthetic dermatology, now available in a topical serum. Optimizes performance at a cellular level, ensuring repair signals reach the dermis where structural renewal begins.

Pro-Scaffolding Peptide Architecture — Acetyl Hexapeptide-8 + Palmitoyl Tripeptide-5: Acetyl Hexapeptide-8 reduces the appearance of expression lines through neuromodulating signaling mechanisms. Palmitoyl Tripeptide-5 activates TGF-beta pathways associated with collagen production and extracellular matrix reinforcement. Together, they support visible smoothing while strengthening dermal architecture at depth.

Amalfi Marine Biomimetic Support Matrix — Hydrolyzed Algin, Hydrolyzed, Rhodophyceae Extract, Chondrus Crispus Extract, Plankton Extract, Mineral-Rich Sea Water:
A mineral and polysaccharide complex drawn from the bioactive-rich coastline of the Amalfi Coast, the ecological foundation of Amalfi Born Biotechnology™. Supports extracellular hydration, reinforces elasticity, improves barrier integrity, and provides glycosaminoglycan support for tensile skin resilience.

Ingredients: Aqua (Water), Glycerin, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-5, Citrus Reticulata (Tangerine) Fruit Extract, Pistacia Lentiscus (Mastic) Gum, Sodium Hyaluronate, Saccharide Isomerate, Aloe Barbadensis Leaf Extract, Helianthus Annuus (Sunflower) Sprout Extract, Hydrolyzed Algin, Plankton Extract, Sodium DNA, Hydrolyzed DNA, Lycium Barbarum Callus Culture Extract, Niacinamide, Chondrus Crispus Extract, Hydrolyzed Rhodophyceae Extract, Maris Aqua (Sea Water), Lecithin, Maltodextrin, Sucrose, Propanediol, Pentylene Glycol, Butylene Glycol, Phenethyl Alcohol, Glyceryl Caprylate, Glyceryl Caprate.

Doesn't Contain: Parabens, phthalates, sulfates, hydroquinone, formaldehyde, ethanolamines (MEA/DEA/TEA), BHA/BHT, triclosan/triclocarban, petrolatum, silicones, synthetic fragrance, artificial colors and plastic beads. Gluten free. Certified vegan and cruelty-free. Made in the USA.

Don’t just take our word for it.

Layout A — current

DNA-42 Clinicalift Serum™

Clinical results

In 42 days

8

years younger

15.3%

less wrinkle depth

In 56 days

11%

less wrinkle depth vs placebo

+6%

more skin density

Clinical studies of the serum’s key actives, not the finished formula.

  1. In 42 days. Randomized, placebo-controlled study of the serum’s key regenerative active at 2%, women aged 52–65, twice daily, 42 days. Primos 3D wrinkle analysis; 8.2 years at day 42 against a reference dataset of 300+ women. Results are for the active, not the finished formula.
  2. In 56 days. PhytoCellTec™ Exosomes at 0.4%, half-face versus placebo, 23 women aged 41–69, twice daily, 56 days, PRIMOS lite. Density by ultrasound, 28 days. Results are for the active, not the finished formula.

Layout B — Augustinus Bader pattern

Proven results

8

Years younger in 42 days

15.3%

Less wrinkle depth in 42 days

11%

Less wrinkle depth vs placebo in 56 days

Based on randomized, placebo-controlled clinical studies of the serum’s key actives. Results are for the actives, not the finished formula.

+266%

Regeneration vs salmon-derived PDRN

+111%

NAMPT expression, the enzyme that recycles NAD+

+161%

FGF7 growth-factor expression

In vitro and ex vivo laboratory testing. Laboratory data is not a clinical result.

Before / After

Visible improvement of aging signs after 42 days

BeforeBefore
After
After
Amalfi Coast

Amalfi Born Biotechnology™

The Amalfi Coast is not just one of the world’s most beautiful coastlines. It is one of its most demanding. Shaped by the Campanian volcanic arc, its soils are saturated with ancient mineral deposits: sulfur, potassium, magnesium, and trace elements forged under intense geological pressure.

The species that thrive anyway are classified as extremophiles: organisms that have evolved not just to tolerate extreme conditions, but to flourish under them. Amalfi Born Biotechnology™ is our proprietary research platform for translating those cellular resilience mechanisms into measurable pathways for human skin.

Why you will love it

Cruelty free

Clean ingredients

Gluten free

Vegan

Made in USA

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